Bile salts induce resistance to polymyxin in enterohemorrhagic Escherichia coli O157:H7.

胆汁酸可诱导肠出血性大肠杆菌 O157:H7 对多粘菌素产生耐药性

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作者:Kus Julianne V, Gebremedhin Ahferom, Dang Vica, Tran Seav-Ly, Serbanescu Anca, Barnett Foster Debora
Many enteric bacteria use bile as an environmental cue to signal resistance and virulence gene expression. Microarray analysis of enterohemorrhagic Escherichia coli O157:H7 (EHEC) treated with bile salts revealed upregulation of genes for an efflux system (acrAB), a two-component signal transduction system (basRS/pmrAB), and lipid A modification (arnBCADTEF and ugd). Bile salt treatment of EHEC produced a basS- and arnT-dependent resistance to polymyxin.

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