Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution.

胃腺癌进展和演变中的空间分辨肿瘤生态系统和细胞状态

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作者：Ma Haoran,Srivastava Supriya,Ho Shamaine Wei Ting,Xu Chang,Lian Benedict Shi Xiang,Ong Xuewen,Tay Su Ting,Sheng Taotao,Lum Huey Yew Jeffrey,Abdul Ghani Siti Aishah Binte,Chu Yunqiang,Huang Kie Kyon,Goh Yeek Teck,Lee Minghui,Hagihara Takeshi,Ng Clara Shi Ya,Tan Angie Lay Keng,Zhang Yanrong,Ding Zichen,Zhu Feng,Ng Michelle Shu Wen,Joseph Craig Ryan Cecil,Chen Hui,Li Zhen,Zhao Joseph J,Rha Sun Young,Teh Ming,Yeong Joe,Yong Wei Peng,So Jimmy Bok-Yan,Sundar Raghav,Tan Patrick
期刊：Cancer Discovery影响因子：33.300
时间：2025起止号：2025 Apr 2; 15(4):767-792
doi：10.1158/2159-8290.CD-24-0605研究方向： 肿瘤
疾病类型： 胃癌
Integration of spatial transcriptomic (GeoMx Digital Spatial Profiler) and single-cell RNA sequencing data from multiple gastric cancers identifies spatially resolved expression-based intratumoral heterogeneity, associated with distinct immune microenvironments. We uncovered two separate evolutionary trajectories associated with specific molecular subtypes, clinical prognoses, stromal neighborhoods, and genetic drivers. Tumor-stroma interfaces emerged as a unique state of tumor ecology.

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