The utilization of gaseous carbon dioxide instead of bicarbonate would greatly facilitate process development for enzyme catalyzed carboxylations on a large scale. As a proof-of-concept, 1,3-dihydroxybenzene (resorcinol) was carboxylated in the ortho-position using pressurized CO(2) (â¼30-40 bar) catalyzed by ortho-benzoic acid decarboxylases with up to 68% conversion. Optimization studies revealed tight pH-control and enzyme stability as the most important determinants.
Pressurized CO(2) as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol.
加压 CO(2) 作为羧化剂用于间苯二酚的生物催化邻位羧化
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| 期刊： | Green Chemistry | 影响因子： | 9.200 |
| 时间： | 2018 | 起止号： | 2018 Apr 21; 20(8):1754-1759 |
| doi： | 10.1039/c8gc00008e | ||
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