Survivin Promotes Stem Cell Competence for Skin Cancer Initiation.

Survivin促进干细胞能力,从而引发皮肤癌

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作者:Canato Sara, Sarate Rahul, Carvalho-Marques Sofia, Maia Soares Raquel, Song Yura, Monteiro-Ferreira Sara, Vieugué Pauline, Liagre Mélanie, Grossi Giancarlo, Cardoso Erik, Dubois Christine, Conway Edward M, Schenone Silvia, Sánchez-Danés Adriana, Blanpain Cédric
This study identifies Survivin as a key regulator of the different ability of SCs and Ps to initiate skin cancer. Survivin expression in oncogene-targeted SCs is essential for their survival and self-renewal and to prevent their differentiation and apoptosis, allowing SCs and not Ps to initiate skin cancer.

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