This study identifies Survivin as a key regulator of the different ability of SCs and Ps to initiate skin cancer. Survivin expression in oncogene-targeted SCs is essential for their survival and self-renewal and to prevent their differentiation and apoptosis, allowing SCs and not Ps to initiate skin cancer.
Survivin Promotes Stem Cell Competence for Skin Cancer Initiation.
Survivin促进干细胞能力,从而引发皮肤癌
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作者:Canato Sara, Sarate Rahul, Carvalho-Marques Sofia, Maia Soares Raquel, Song Yura, Monteiro-Ferreira Sara, Vieugué Pauline, Liagre Mélanie, Grossi Giancarlo, Cardoso Erik, Dubois Christine, Conway Edward M, Schenone Silvia, Sánchez-Danés Adriana, Blanpain Cédric
| 期刊: | Cancer Discovery | 影响因子: | 33.300 |
| 时间: | 2025 | 起止号: | 2025 Feb 7; 15(2):427-443 |
| doi: | 10.1158/2159-8290.CD-24-0263 | 研究方向: | 发育与干细胞、细胞生物学 |
| 疾病类型: | 皮肤癌 | ||
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