The thymus is the site of T cell maturation. Notch receptors (Notch1-4) and ligands (DLL1-3 and Jagged1-2) constitute one of several pathways involved in this process. Our data revealed differential constitutive expression of Notch genes and ligands in T lymphocytes and thymic dendritic cells (tDCs), suggesting their participation in human thymocyte maturation. nTreg analyses indicated that the Notch components function in parallel to promote maturation in the thymus.
Constitutive expression of genes encoding notch receptors and ligands in developing lymphocytes, nTreg cells and dendritic cells in the human thymus.
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作者：Bento-de-Souza Luciana, Victor Jefferson R, Bento-de-Souza Luiz C, Arrais-Santos Magaly, Rangel-Santos Andréia C, Pereira-Costa Ãrica, Raniero-Fernandes Elaine, Seixas-Duarte Maria I, Oliveira-Filho João B, Silva Duarte Alberto J
| 期刊： | Results Immunol | 影响因子： | 0.000 |
| 时间： | 2016 | 起止号： | 2016 Apr 5; 6:15-20 |
| doi： | 10.1016/j.rinim.2016.04.001 | ||
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