Voltammetric Determination of Ivabradine Hydrochloride Using Multiwalled Carbon Nanotubes Modified Electrode in Presence of Sodium Dodecyl Sulfate

十二烷基硫酸钠存在下多壁碳纳米管修饰电极伏安法测定盐酸伊伐布雷定

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作者:Ali Kamal Attia, Nisreen Farouk Abo-Talib, Marwa Hosny Tammam

Conclusion

This method is suitable for determination of IH in tablets and plasma.

Methods

The electrochemical behavior of IH was studied in Britton-Robinson buffer (pH: 2.0-11.0) using cyclic and differential pulse voltammetry.

Purpose

A new sensitive sensor was fabricated for the determination of ivabradine hydrochloride (IH) based on modification with multiwalled carbon nanotubes using sodium dodecyl sulfate as micellar medium to increase the sensitivity.

Results

The voltammetric response was linear over the range of 3.984 x 10-6-3.475 x 10-5 mol L-1. The limits of detection and quantification were found to be 5.160 x 10-7 and 1.720 x 10-6 mol L-1, respectively.

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