Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids

5-取代的罗丹宁-3-羧烷基酸衍生物的抗菌性能

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作者:Waldemar Tejchman, Izabela Korona-Glowniak, Anna Malm, Marek Zylewski, Piotr Suder

Abstract

A series of rhodanine 3-carboxyalkanoic acid derivatives possessing 4'-(N,N-dialkyl-amino or diphenylamino)-benzylidene moiety as a substituent at the C-5 position were synthesised and their antibacterial activity was screened. All the rhodanine derivatives showed bacteriostatic or bactericidal activity to the reference gram-positive bacterial strains, but lack of activity to the reference Gram-negative bacterial strains and yeast strains was observed.

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