In 2000, at the Université d'Auvergne teaching hospital in Clermont-Ferrand, France, 44 (6.2%) strains of Pseudomonas aeruginosa were found to be resistant to ceftazidime. After genotyping, 34 strains were selected. Nine had an additional beta-lactamase: OXA-21 (n = 6), PSE-1 (CARB-2) (n = 2), or PER-1 (n = 1). Ceftazidime resistance was related solely to the overproduction of the cephalosporinase in 30 strains. Sequencing of five bla(AmpC) genes encoding cephalosporinases with different pIs showed 99% identity with the ampC gene of P. aeruginosa PAO1.
Prospective survey of beta-lactamases produced by ceftazidime- resistant Pseudomonas aeruginosa isolated in a French hospital in 2000.
对 2000 年在法国一家医院分离出的头孢他啶耐药铜绿假单胞菌产生的 β-内酰胺酶进行前瞻性调查
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作者：De Champs Christophe, Poirel Laurent, Bonnet Richard, Sirot Danielle, Chanal Catherine, Sirot Jacques, Nordmann Patrice
| 期刊： | Antimicrobial Agents and Chemotherapy | 影响因子： | 4.500 |
| 时间： | 2002 | 起止号： | 2002 Sep;46(9):3031-4 |
| doi： | 10.1128/AAC.46.9.3031-3034.2002 | 研究方向： | 微生物学 |
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