Trans-resveratrol restores the damages induced by organophosphate pesticide-monocrotophos in neuronal cells.

The restorative potential of trans-resveratrol (RV) was investigated in a rat neuronal cell line (PC12) exposed to organophosphate pesticide-monocrotophos (MCP). RV shows significant protection against MCP-induced alterations in PC12 cells by restoration of oxidative stress-mediated apoptosis and cytotoxicity. RV treatment significantly reduced reactive oxygen species (ROS) production and lipid peroxidation, and also restored glutathione levels and mitochondrial membrane potential, in cells receiving MCP. Restoration of markers such as cytochrome c, Bax, Bcl-2 and caspase-3 also confirms the effectiveness of RV against MCP-induced, mitochondria-mediated apoptosis in PC12 cells. The data identify the protective/restorative potential of RV against MCP-induced neuronal damages by affecting ROS production and the level of antioxidant defence enzymes.