Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation. These compounds were analyzed for phosphodiesterase (PDE) inhibition indirectly by motility pattern in human spermatozoa. Some of the synthesized compounds, namely, 5d, 5e, 5f, 5g, 5h, and 5k, have exhibited potent inhibitory activity on PDE.
Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors.
香豆素衍生物作为PDE抑制剂的设计与微波辅助合成
阅读：5
作者：Kumbar Mahadev N, Kamble Ravindra R, Kamble Atulkumar A, Salian Sujith Raj, Kumari Sandhya, Nair Ramya, Kalthur Guruprasad, Adiga Satish Kumar, Prasad D Jagadeesh
| 期刊： | International Journal of Medicinal Chemistry | 影响因子： | 0.000 |
| 时间： | 2016 | 起止号： | 2016;2016:9890630 |
| doi： | 10.1155/2016/9890630 | 研究方向： | 信号转导 |
特别声明
1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。
2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。
3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。
4、投稿及合作请联系：info@biocloudy.com。