Fusobacterium nucleatum Load Correlates with KRAS Mutation and Sessile Serrated Pathogenesis in Colorectal Adenocarcinoma

具核梭杆菌负荷与结直肠腺癌中的 KRAS 突变和无柄锯齿状发病机制相关

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作者:Koki Takeda #, Minoru Koi #, Yoshiki Okita, Sija Sajibu, Temitope O Keku, John M Carethers

Significance

The authors demonstrated that Fn is enriched in colorectal cancers exhibiting the SSP phenotype, and in colorectal cancers carrying KRAS mutations. Fn infection should be considered as a candidate risk factor specific to colorectal cancers with the SSP phenotype and with KRAS mutations.

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