Adaptive Mish activation and ranger optimizer-based SEA-ResNet50 model with explainable AI for multiclass classification of COVID-19 chest X-ray images.

A recent global health crisis, COVID-19 is a significant global health crisis that has profoundly affected lifestyles. The detection of such diseases from similar thoracic anomalies using medical images is a challenging task. Thus, the requirement of an end-to-end automated system is vastly necessary in clinical treatments. In this way, the work proposes a Squeeze-and-Excitation Attention-based ResNet50 (SEA-ResNet50) model for detecting COVID-19 utilizing chest X-ray data. Here, the idea lies in improving the residual units of ResNet50 using the squeeze-and-excitation attention mechanism. For further enhancement, the Ranger optimizer and adaptive Mish activation function are employed to improve the feature learning of the SEA-ResNet50 model. For evaluation, two publicly available COVID-19 radiographic datasets are utilized. The chest X-ray input images are augmented during experimentation for robust evaluation against four output classes namely normal, pneumonia, lung opacity, and COVID-19. Then a comparative study is done for the SEA-ResNet50 model against VGG-16, Xception, ResNet18, ResNet50, and DenseNet121 architectures. The proposed framework of SEA-ResNet50 together with the Ranger optimizer and adaptive Mish activation provided maximum classification accuracies of 98.38% (multiclass) and 99.29% (binary classification) as compared with the existing CNN architectures. The proposed method achieved the highest Kappa validation scores of 0.975 (multiclass) and 0.98 (binary classification) over others. Furthermore, the visualization of the saliency maps of the abnormal regions is represented using the explainable artificial intelligence (XAI) model, thereby enhancing interpretability in disease diagnosis.