New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

从狭叶瑞香(Daphniphyllum angustifolium Hutch)中分离得到具有细胞毒活性的新型塞可达芬烷型生物碱。

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作者:Qing-Yun Lu # ,Jia-Hui Zhang # ,Ying-Yao Li ,Xue-Xue Pu ,Cui-Shan Zhang ,Shuai Liu ,Jia-Jia Wan ,Ying-Tong Di ,Xiao-Jiang Hao

Abstract

One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC50 of 31.9 μM. Keywords: Cytotoxic activity; Daphnioldhanol A; Daphniphyllum angustifolium hutch; Secodaphnane-type.

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