Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells.

BACKGROUND: Research on the function of HGH1 in breast cancer remains lacking. METHODS: TCGAand GEO (GSE45827) datasets investigated discrepancies in HGH1 expression in BC. An aggregate of 106 clinical samples were gathered through immunohistochemistry, KM curves were drawn for prognostic analysis, and the function of HGH1 of BC was predicted. Finally, the effects of HGH1 knockdown on MDA-MB-231 and MCF-7 BC cells were verified via CCK8, invasion, wound healing and colony formation assays. RESULTS: HGH1 is highly expressed in BC and is linked to unfavorable prognosis. HGH1 overexpression is connected to keratinization and the cell cycle and is closely related to ER and PR expression and tumor stage in BC patients. Knocking down HGH1 in BC cells inhibited the viability, invasion and migration. CONCLUSION: Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells.