Multi-column continuous chromatography effectively improves the robustness of bind-elute mode chromatography in which a pre-elution wash is applied to reduce weakly bound impurities and charge variants

多柱连续色谱法有效提高了结合-洗脱模式色谱法的稳健性，其中采用预洗脱洗涤来减少弱结合杂质和电荷变体。