Dexmedetomidine alleviates pain in MPTP-treated mice by activating the AMPK/mTOR/NF-κB pathways in astrocytes
右美托咪啶通过激活星形胶质细胞中的 AMPK/mTOR/NF-κB 通路缓解 MPTP 治疗小鼠的疼痛
阅读:5
作者:Yaohua Chen, Yuping Li, Chunxiang Li, Dan Zhu, Oumei Cheng, Jian Cui
| 期刊: | Neuroscience Letters | 影响因子: | 2.500 |
| 时间: | 2022 | 起止号: | 2022 Nov 20:791:136933. |
| doi: | 10.1016/j.neulet.2022.136933 | 研究方向: | 信号转导 |
| 细胞类型: | 胶质细胞 | 信号通路: | AMPK、NF-κB、mTOR |
Conclusions
These findings reveal that Dex protects dopaminergic neurons in PD and alleviates pain by reducing the activation of DHSC astrocytes through the AMPK/mTOR/NF-κB pathway. Therefore, Dex may be a potential drug for treating Parkinson's pain.
特别声明
1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。
2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。
3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。
4、投稿及合作请联系:info@biocloudy.com。