Abstract
Three complexes, namely [Co(dmtp)&sub2;(OH&sub2;)&sub4;][CoCl&sub4;] (1), [Co(dmtp)&sub2;Cl&sub2;] (2) and [Co(dmtp)&sub2;(OH&sub2;)&sub4;]Cl&sub2;∙2H&sub2;O (3) (dmtp: 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine), were synthesized and characterized by spectral (IR, UV-Vis-NIR), and magnetic measurements at room temperature, as well as single crystal X-ray diffraction. Complex (1) crystallizes in monoclinic system (space group C2/c), complex (2) adopts an orthorhombic system (space group Pbca), and complex (3) crystallizes in triclinic system (space group P1). Various types of extended hydrogen bonds and π-π interactions provide a supramolecular architecture for all complexes. All species were evaluated for antimicrobial activity towards planktonic and biofilm-embedded microbial cells and influence on HEp-2 cell viability, cellular cycle and gene expression.