Inducible Activation of MyD88 and CD40 in CAR T Cells Results in Controllable and Potent Antitumor Activity in Preclinical Solid Tumor Models
CAR-T 细胞中 MyD88 和 CD40 的诱导激活可在临床前实体瘤模型中产生可控且有效的抗肿瘤活性
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作者:Melinda Mata, Claudia Gerken, Phuong Nguyen, Giedre Krenciute, David M Spencer, Stephen Gottschalk
| 期刊: | Cancer Discovery | 影响因子: | 29.700 |
| 时间: | 2017 | 起止号: | 2017 Nov;7(11):1306-1319. |
| doi: | 10.1158/2159-8290.CD-17-0263 | 研究方向: | 肿瘤 |
| 细胞类型: | T细胞 | |
Significance
Inducible activation of MyD88 and CD40 in CAR T cells with a small-molecule drug not only enhances their effector function, resulting in potent antitumor activity in preclinical solid tumors, but also enables their remote control post infusion. Cancer Discov; 7(11); 1306-19. ©2017 AACR.This article is highlighted in the In This Issue feature, p. 1201.
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