Abstract
Objective: To evaluate the wound-healing activity of oil of Hypercium perforatum (St. John's wort), in excision wounds of male white rats. Approach: The current methods of wound management involve the use of antibiotic creams. The search for more natural materials for the purpose of healing of wounds has led to the discoveries of potential agents prepared from plant extracts. Hyperforin and Hypericin are important phytochemical constituents found in H. perforatum, which have been highlighted for their antimicrobial, antiviral, and anti-inflammatory properties in recent times. Therefore, we have attempted to explore the wound-healing activity of oil obtained from H. perforatum.Results:H. perforatum oil emulsion has been demonstrated to have significant wound-healing potential as compared with mupirocin ointment and petroleum jelly (Vaseline). Animals treated with H. perforatum showed a 97% (18.9 mm(2)/day) reduction in wound area as compared with animals treated with mupirocin (68%) (12.8 mm(2)/day) and animals treated with Vaseline (69%) (13.7 mm(2)/day). X-ray analysis of skin of animals treated with H. perforatum showed a significant increase in angiogenesis as compared with other groups in the study. Innovation: This study identified the wound-healing activity of oil of H. perforatum.Conclusion: The findings of this study support the wound-healing potential of H. perforatum along with other therapeutic uses.