Abstract
WHAT IS ALREADY KNOWN ON THIS TOPIC? Genital herpes infection is a chronic condition that can cause recurrent symptoms, significantly affecting both quality of life and sexual relationships. However, there is currently no available data on the global trends and regional variations in the incidence of genital herpes among individuals of reproductive age. WHAT IS ADDED BY THIS REPORT? From 1990 to 2021, there was a 51.97% increase in global incident cases of genital herpes among individuals aged 15-49 years. The incidence rates also rose in low-middle socio-demographic index region, South Asia, Southern Sub-Saharan Africa, and Central Europe. Among these regions, countries in Southern Sub-Saharan Africa experienced the highest burden of genital herpes among individuals aged 15-49 years. WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE? Given the rise in global incident cases and incidence rates in some regions among individuals of reproductive age from 1990 to 2021, it is imperative to prioritize the implementation of preventive strategies and interventions for genital herpes infection. This includes a significant focus on the development of vaccines.