Emerging Sialylated Class R Lipooligosaccharides in Campylobacter jejuni from Seagulls Has the Potential to Trigger Guillain-Barré Syndrome - Yunnan Province, China, 2018-2023

海鸥空肠弯曲菌中新出现的唾液酸化R类脂寡糖可能诱发格林-巴利综合征——中国云南省,2018-2023年

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Abstract

WHAT IS ALREADY KNOWN ABOUT THIS TOPIC? Lipooligosaccharides from Campylobacter jejuni (C. jejuni) have a mimicry antigen structure with gangliosides, which explains the mechanism by which C. jejuni caused Guillain-Barré syndrome (GBS). WHAT IS ADDED BY THIS REPORT? All 12 C. jejuni strains with class R LOSs and specific serotypes were isolated from seagulls in south China. These emerging C. jejuni strains had ganglioside-mimicry antigen structures and possessed a high potential for triggering GBS. WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE? Sialylated lipooligosaccharides (LOS) class R with GBS-associated serotypes isolated from seagulls highlight the risk of induced GBS around coastal or lakeside areas.

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