Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome

胃癌中黏蛋白相关唾液酸Tn抗原的表达与不良预后相关。

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Abstract

The expression of sialosyl-Tn (STn) antigen was evaluated by immunohistochemistry in primary gastric cancers. Twenty-one of 31 (68%) gastric cancers expressed STn, regardless of tumour location, stage or histological type. Eighty-one per cent of patients with STn-positive tumours died of their disease or had recurrent cancer, compared with 20% of patients with STn-negative tumours (P < 0.002). STn may be a useful prognostic marker in patients with gastric cancer.

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