Generation of the human pluripotent stem cell lines KUMi005-A from a patients with multiple myeloma

从多发性骨髓瘤患者体内生成人类多能干细胞系 KUMi005-A

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作者:Ji-Hea Kim, Ji-Hyeon Hong, Ka-Won Kang, Byung-Hyun Lee, Young Park, Byung-Soo Kim

Abstract

Multiple myeloma (MM) progresses with abnormal monoclonal proliferation and accumulation of malignant plasma cells in the bone marrow. We established human induced pluripotent stem cells (iPSCs), KUMi005-A, from bone marrow samples of a patient with MM. This reprogrammed cell line has similar characteristics to human embryonic stem cells, such as proliferation properties and pluripotency. KUMi005-A iPSCs may be applicable in MM disease modeling and cell-based therapies.

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