Anti-Mullerian hormone attenuates both cyclophosphamide-induced damage and PI3K signalling activation, while rapamycin attenuates only PI3K signalling activation, in human ovarian cortex in vitro

在体外人类卵巢皮质中,抗苗勒氏管激素可减弱环磷酰胺引起的损伤和 PI3K 信号激活,而雷帕霉素仅可减弱 PI3K 信号激活

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作者:Roseanne Rosario, Hazel L Stewart, Norah Spears, Evelyn E Telfer, Richard A Anderson

Methods

Histological analysis of ovarian tissue was undertaken for follicle staging and health assessment. Western blotting and immunostaining were used to assess activation of PI3K signalling by measuring phosphorylation of AKT and phosphorylated FOXO3A staining intensity, respectively. Main

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