Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats

摄入大西洋鳕鱼残渣可减轻肥胖 Zucker fa/fa 大鼠的血压升高,但不会延缓肾脏损害的发展

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作者:Iselin Vildmyren, Åge Oterhals, Sabine Leh, Tor Andreas Samuelsen, Alfred Halstensen, Hans-Peter Marti, Oddrun Anita Gudbrandsen

Background

Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary

Conclusion

A diet containing a protein powder consisting of HBS fraction from cod attenuated the blood pressure increase in obese Zucker fa/fa rats, without preventing kidney damage.

Methods

Male rats were fed diets containing protein powder prepared from head, backbone and skin fraction (HBS, n = 6) from Atlantic cod as 25% of total protein with the remaining 75% as casein, or casein as the sole protein source (Control group, n = 6) for 4 weeks. Blood pressure was measured on day 0, 14 and 26. Kidneys were analysed morphologically, and markers for renal function and organ damage were analysed biochemically.

Results

The HBS diet attenuated the blood pressure increase compared to the Control group, but kidney damage and dysfunction were similar between the two groups.

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