Abstract
BACKGROUND AND OBJECTIVES: Although the prevention of the neuropsychological consequences of congenital hypothyroidism (CH) through the use of replacement therapy represents an important public health success, knowledge about the modifiable risk factors could reduce the number of infants affected by this disease. This study was carried out to identify risk factors for CH at Fayoum Governorate, Egypt. DESIGN AND SETTINGS: This was a population-based case-control study, which started in 2003 and was carried out for 8 years through Fayoum center of the Egyptian Ministry of Health and Population screening program for CH. METHODS: This study was a population-based case-control study carried out by using national project for CH. One control was enrolled for each new CH infant; 320 cases and 320 controls were enrolled in 8 years. Maternal and neonatal influences were investigated. RESULTS: A statistically significant association of CH was observed with birth defects, female gender, gestational age > 40 weeks, and gestational diabetes. An increased risk for CH was detected in twins by a multivariate analysis. CONCLUSION: Our results suggest a multifactorial origin of CH in which genetic (high frequency of additional malformations) and environmental factors (especially maternal diabetes) play a role in the development of the disease.