Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus

接种诺如病毒的志愿者体内针对诺如病毒基因群GI.1和GII.4蛋白酶的抗体反应

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作者：Ajami,Nadim J,Barry,Meagan A,Carrillo,Berenice,Muhaxhiri,Zana,Neill,Frederick H,Prasad,B V Venkataram,Opekun,Antone R,Gilger,Mark A,Graham,David Y,Atmar,Robert L,Estes,Mary K
期刊：Clinical and Vaccine Immunology影响因子：0.000
时间：2012起止号：2012 Dec;19(12):1980-3
doi：10.1128/CVI.00411-12研究方向： 微生物学

Abstract

An assay was developed to detect antibodies against two norovirus proteases among participants in a Norwalk virus (GI.1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from a heterologous GII.4 strain. Seroresponses were detected for 14 of 19 (74%) infected persons.

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