Insight into temperature-dependent microRNA function in mammalian hibernators: Perspectives on cold-influenced microRNA/target interaction

Mammalian hibernation involves re-programming of metabolic functions, in part, facilitated by microRNA. Although much is known about microRNA function, we lack knowledge on low temperature microRNA target selection. It is possible that the thermodynamics of microRNA target selection could dictate unique temperature-dependent sets of microRNA targets for hibernators.