Conclusions
These findings suggest that all five of the test compounds produced Δ9-THC-like effects and will likely have abuse liability similar to that of the controlled cannabinoid compounds.
Methods
Five of these compounds (BB-22, FUB-PB-22, 5F-AMB, NM2201, and MAB-CHMINACA) were tested for their ability to produce discriminative stimulus effects similar to Δ9-tetrahydrocannabinol (Δ9-THC) in rats. The ability of the CB1 receptor inverse agonist rimonabant to antagonize the discriminative stimulus effects of the five test compounds was also tested.
Results
All five of the test compounds fully substituted for the discriminative stimulus effects of Δ9-THC at some dose, although MAB-CHMINACA produced an inverted U-shaped dose effect. Rimonabant fully antagonized the Δ9-THC-like discriminative stimulus effects of BB-22, 5F-AMB, NM2201, and MAB-CHMINACA but only reduced the effects of FUB-PB-22 to 40-50 % of Δ9-THC-appropriate responding. Conclusions: These findings suggest that all five of the test compounds produced Δ9-THC-like effects and will likely have abuse liability similar to that of the controlled cannabinoid compounds.