Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions
去甲肾上腺素通过泛素化连接蛋白 43 间隙连接抑制大鼠心肌细胞间偶联
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作者：Sarah Mollerup, Johannes P Hofgaard, Thomas H Braunstein, Ane Kjenseth, Edward Leithe, Edgar Rivedal, Niels-Henrik Holstein-Rathlou, Morten Schak Nielsen
Conclusions
Norepinephrine increases ubiquitination of Cx43 in cardiomyocytes, possibly via Nedd4. We suggest that Cx43 is subsequently internalized, which is preceded by acquired solubility in Triton X-100, which does not lead to uncoupling per se.
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