Abstract
The threat of emerging infections grows with the swelling tide of the human population and the continued disregard for the health of the environment. One of our most urgent challenges in public health is to understand the evolution and natural history of pathogens and parasites and how a sudden shift in virulence or in targeted host population may occur without warning. Viruses call for especially close watching. They are mostly genes and have mastered the art of manipulating other genes. Some are planktonic in the world's oceans, numbering 10 billion per liter of seawater; some are planktonic in our blood; some lie low inside cells; some take over a cell's replication machinery and explode the cell with new copies of themselves; and some splice their genes seamlessly into our chromosomes. The twin themes of genetic diversity and natural selection are explored in this review, with their relevance to viruses, the vertebrate immune system, virulence, and communicable disease epidemiology.