SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL 2-THIO DERIVATIVES OF ATP

2-Alkylthio analogues of adenosine 5'-triphosphate were synthesized and evaluated as P(2y) purinoceptor agonists. ATP and analogues transiently increased intracellular Ca(2+) levels in C6 glioma cells and in skeletal muscle derived myotubes in culture. Most derivatives were resistant to stepwise dephosphorylation by ecto-ATPases.