Oral supplementation with ginseng polysaccharide promotes food intake in mice

口服人参多糖可促进小鼠食物摄入

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作者:Jiawen Wang, Yongxiang Li, Pei Luo, Yuhuang Chen, Qianyun Xi, Hanyu Wu, Weijie Zhao, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Yongliang Zhang, Qingyan Jiang, Lina Wang

Results

Ginseng polysaccharide significantly increased the average daily food intake in mice and promoted hedonic eating behavior. Meanwhile, the levels of serum glucose and glucagon were significantly reduced by GPS, and GPS promoted hypothalamic neuropeptide Y expression, inhibited proopiomelanocortin (POMC) expression, and reduced dopamine D1 receptor (DRD1) levels in the midbrain. We also found that the anxiety level of mice was significantly lower after GPS intake. In

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