Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors

1,3,5-三嗪氨基酸衍生物的合成及初步生物学评价及其MAO抑制剂的研究

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作者:Sherine N Khattab, Hosam H Khalil, Adnan A Bekhit, Mohamed Mokbel Abd El-Rahman, Ayman El-Faham, Fernando Albericio

Abstract

Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity.

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