Expression of mir-21 and mir-143 in cervical specimens ranging from histologically normal through to invasive cervical cancer

MicroRNA expression is severely disrupted in carcinogenesis, however limited evidence is available validating

Whilst microRNA biomarkers have a number of promising features, more studies on expression levels in histologically defined clinical specimens are required to investigate clinical relevance of discovery-based studies. Mir-21 may be of some utility in predictive screening, given that we observed a significant correlation between mir-21 expression level and worsening histological diagnosis of cervical cancer.