Abstract
Nanotechnology and engineered nanomaterials have been at the forefront of technological breakthroughs of the 21st century. With the challenges of increasingly complex and emergent environmental pollution, nanotechnology offers exciting complementary approaches to achieve high efficiencies with low or green energy input. However, unknown and unintended hazardous effects and health risks associated with nanotechnology hinder its full-scale implementation. Therefore, the development of safer nanomaterials lies in the critical balance between the applications and implications of nanomaterials. To facilitate constructive dialogue between the two sides (i.e., applications and implications) of the same coin, this review sets forth to summarize the current progress of the environmental applications of nanomaterials and establish the structure-property-functionality relationship. A systematic analysis of the structure-property-toxicity relationship is also provided to advocate the Safe and Sustainable-by-Design strategy for nanomaterials. Lastly, the review also discusses the future of artificial intelligence-assisted environmental health and safety-oriented development of nanomaterials.