Use of YbIII-centered near-infrared (NIR) luminescence to determine the hydration state of a 3,2-HOPO-based MRI contrast agent

利用以YbIII为中心的近红外(NIR)发光测定基于3,2-HOPO的MRI造影剂的水合状态

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Abstract

The synthesis, structure, and characterization of a [Yb(Tren-Me-3,2-HOPO)(H 2O) 2] complex are reported. As a result of its Yb (III) emission in the near-infrared region, sensitized by the Me-3,2-HOPO chromophore, this complex can be utilized for the first time to determine the hydration state, q, via the luminescence lifetimes and hence the solution structure of these Me-3,2-HOPO-type ligands, which have attracted significant interest in complex with Gd (III) as possible next-generation magnetic resonance imaging contrast agents.

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