Photodynamic production of superoxide in vitro by altertoxins in the presence of reducing agents

在还原剂存在下,通过光动力法在体外利用毒素产生超氧化物

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Abstract

Superoxide production by the three 4,9-dihydroxyperylene-3,10-quinone fungal toxins, altertoxins I, II, and III, was stimulated on illumination with broad-spectrum light. As determined previously for cercosporin, superoxide production by illuminated altertoxins was increased by the addition of the reducing substances ergothioneine or urate; ascorbate also effectively increased superoxide production. Illuminated urate alone engendered some superoxide production.

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