Abstract
Seamless integration of the body and electronics toward the understanding, quantification, and control of disease states remains one of the grand scientific challenges of this era. As such, research efforts have been dedicated to developing bioelectronic devices for chemical, mechanical, and electrical sensing, and cellular and tissue functionality modulation. The technologies developed to achieve these capabilities cross a wide range of materials and scale (and dimensionality), e.g., from micrometer to centimeters (from 2-dimensional (2D) to 3-dimensional (3D) assemblies). The integration into multimodal systems which allow greater insight and control into intrinsically multifaceted biological systems requires careful design and selection. This snapshot review will highlight the state-of-the-art in cellular recording and modulation as well as the material considerations for the design and manufacturing of devices integrating their capabilities.