Abstract
Electrosynthesis represents a dynamic field in organic chemistry for the development of important and selective reactions. Among the most interesting electrosynthetic transformations is the non-directed arene C-H amination. Despite increasing reports, the quest for a non-directed electrochemical arene C-H amination capable of accommodating a wide range of arenes and amines with high site-selectivity remains ongoing. Non-directed electrochemical C-H amination presents a metal-free, mild approach for synthesizing complex aminated compounds of interest in pharmaceuticals and natural products. This concept aims to introduce the concept of non-directed electrochemical C-H amination and provide an overview of the recent advances in the field as well as the current limitations and potential directions.