Abstract
Manuscript peer review is fundamental to the evaluation and dissemination of modern science; it is the process whereby good science is enhanced and bad science is dismissed. Very little objective evidence, however, has been amassed to guide the manuscript peer review process. Rather, it is learned by experience and mentoring: by doing reviews, receiving reviews of one's own work, and by obtaining feedback from seasoned reviewers. Here, I lay out my perspective on this cornerstone of the scientific endeavor.