Abstract
Leiomyomas are the most common benign esophageal neoplasm. About half of them were smaller than 5 cm and asymptomatic with a stable size for many years. Esophageal leiomyomas that excess than 5 cm in size may develop as a consequence of giant one at rapid growth rate. This case report specifically describes a mid-aged woman who experienced a missed diagnosis of an esophageal leiomyoma over three years, which was covered by mediastinal thymolipoma and it subsequently developed as a giant tumor occupying the entire esophagus that makes the simple enucleation impossible. A surgical intervention of esophagectomy had to be performed to manage this entity.