Intercellular synchronization of diffusively coupled Ca(2+) oscillators

扩散耦合的Ca(2+)振荡器的细胞间同步

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Abstract

We examine the synchrony in the dynamics of localized [Ca(2 + )](i) oscillations among a group of cells exhibiting such complex Ca(2 + ) oscillations, connected in the form of long chain, via diffusing coupling where cytosolic Ca(2 + ) and inositol 1,4,5-triphosphate are coupling molecules. Based on our numerical results, we could able to identify three regimes, namely desynchronized, transition and synchronized regimes in the (T - k(e)) (time period-coupling constant) and (A - k(e)) (amplitude-coupling constant) spaces which are supported by phase plots (Δϕ verses time) and recurrence plots, respectively. We further show the increase of synchronization among the cells as the number of coupling molecules increases in the (T - k(e)) and (A - k(e)) spaces.

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