Efficacy and tolerability of micafungin monotherapy for candidemia and deep-seated candidiasis in adults with cancer

米卡芬净单药治疗成人癌症患者念珠菌血症和深部念珠菌病的疗效和耐受性

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Abstract

The response rate among 58 patients with cancer and candidemia or deep-seated candidiasis treated with micafungin monotherapy was 81%. Intensive care unit (ICU) stay, concomitant nonfungal infections, and acute kidney injury were significantly associated with the 30-day crude mortality rate. Severe neutropenia was an independent predictor of micafungin failure. The efficacy and safety of micafungin in cancer patients with invasive candidiasis were comparable to those reported for patients without malignancy and for cancer patients treated with caspofungin.

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