Co(II)-Catalyzed Picolinamide-Directed C(sp(3))-S Bond Formation with N-(phenylsulfanyl)succinimides

Co(II)催化吡啶甲酰胺导向的N-(苯硫基)琥珀酰亚胺C(sp(3))-S键形成

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Abstract

Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp(3))-H bond formation with N-(phenylsulfanyl)succinimides. This method enables the direct construction of C(sp(3))-S bonds under mild conditions and exhibits excellent functional group tolerance along with a broad substrate scope. Notably, the catalytic system achieves oxidative C-H functionalization without relying on costly or environmentally detrimental oxidants, offering a more sustainable and practical alternative for C-S bond formation.

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