Transition-metal free umpolung carbon-nitrogen vs. carbon-chlorine bond formation

过渡金属不参与的碳氮键与碳氯键的极性反转形成

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Abstract

The formation of carbon-nitrogen (C-N) bonds via an umpolung substitution reaction has been achieved at -78 °C without the need for catalysts, ligands, or additives. The scope is limited to aryl Grignard reagents with N-chloroamines. The findings in this manuscript serve as a reference point for all C-N bond formation involving N-chloroamines and organometallic reagents. Knowing the yields of uncatalyzed reactions will be useful when determining the success of future catalytic methods.

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