Microfluidic cell counter with embedded optical fibers fabricated by femtosecond laser ablation and anodic bonding

采用飞秒激光烧蚀和阳极键合技术制备的内置光纤的微流控细胞计数器

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Abstract

A simple fabrication technique to create all silicon/glass microfluidic devices is demonstrated using femtosecond laser ablation and anodic bonding. In a first application, we constructed a cell counting device based on small angle light scattering. The counter featured embedded optical fibers for multiangle excitation and detection of scattered light and/or fluorescence. The performance of the microfluidic cell counter was benchmarked against a commercial fluorescence-activated cell sorter.

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