Abstract
The manuscript “Eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production” was selected as a Pivotal Advance because it addresses an important and novel function of mouse eosinophils. Although eosinophils are traditionally perceived as end-stage degranulating cells, the results of numerous recent studies have broadened our perspective on eosinophil effector function. In this work, Wang and Weller demonstrate that eosinophils stimulate early B cell responses, notably the production of antigen-specific IgM.