Abstract
Proton-density fat fraction (PDFF) of the paraspinal muscles, derived from chemical shift encoding-based water-fat magnetic resonance imaging, has emerged as an important surrogate biomarker in individuals with intervertebral disc disease, osteoporosis, sarcopenia and neuromuscular disorders. However, quantification of paraspinal muscle PDFF is currently limited in clinical routine due to the required time-consuming manual segmentation procedure. The present study aimed to develop an automatic segmentation algorithm of the lumbar paraspinal muscles based on water-fat sequences and compare the performance of this algorithm to ground truth data based on manual segmentation. The algorithm comprised an average shape model, a dual feature model, associating each surface point with a fat and water image appearance feature, and a detection model. Right and left psoas, quadratus lumborum and erector spinae muscles were automatically segmented. Dice coefficients averaged over all six muscle compartments amounted to 0.83 (range 0.75-0.90).