Modeling human disease in rodents by CRISPR/Cas9 genome editing

利用CRISPR/Cas9基因编辑技术在啮齿动物中模拟人类疾病

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Abstract

Modeling human disease has proven to be a challenge for the scientific community. For years, generating an animal model was complicated and restricted to very few species. With the rise of CRISPR/Cas9, it is now possible to generate more or less any animal model. In this review, we will show how this technology is and will change our way to obtain relevant disease animal models and how it should impact human health.

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